Outbreak of Pantoea agglomerans associated with contaminated parenteral nutrition in a Neonatal Intensive Care Unit

Resumo

Background: Contamination in the Parenteral Nutrition (PN) has been causing sepsis outbreaks. Objectives: The aim of this study was to describe an outbreak of Pantoea agglomerans detected during an epidemiological surveillance that was made in the unit, due to contaminated total parenteral nutrition in a Neonatal Intensive Care Unit (NICU) of a tertiary care hospital. Methods: The study was conducted in the NICU of the Uberlândia University Hospital, Brazil. It was made a surveillance in the unit collecting clinical and epidemiological data from neonates hospitalized from January 2013 to December 2016. All Bacteriologic testing including clinical, parenteral nutrition, environmental samples and hand cultures was performed and microorganisms was identified by using automated biochemical identification system (Vitek 2; bioMérieux). Results: In the first year of the study, an outbreak of bloodstream infection was verified. The cause of this outbreak was contaminated parenteral nutrition. The administration of PN was discontinued immediately All neonates affected had been born prematurely, with gestational age less than 40 weeks. There were no deaths. Discussion: The time to control the outbreak was three months and each step was taken to avoid the recurrence of this outbreak through epidemiological surveillance, which is extremely important for the detection of outbreaks and risk of infection factors